Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo (Science Translational Medicine)

Science Translational Medicine 27 February 2013: Vol. 5, Issue 174, p. 174ra28; Sci. Transl. Med. DOI: 10.1126/scitranslmed.3005127

ABSTRACT

Portada de Science Translational MedicineVitiligo is an autoimmune disease characterized by destruction of melanocytes, leaving 0.5% of the population with progressive depigmentation. Current treatments offer limited efficacy. We report that modified inducible heat shock protein 70 (HSP70i) prevents T cell–mediated depigmentation. HSP70i is the molecular link between stress and the resultant immune response. We previously showed that HSP70i induces an inflammatory dendritic cell (DC) phenotype and is necessary for depigmentation in vitiligo mouse models. Here, we observed a similar DC inflammatory phenotype in vitiligo patients. In a mouse model of depigmentation, DNA vaccination with a melanocyte antigen and the carboxyl terminus of HSP70i was sufficient to drive autoimmunity. Mutational analysis of the HSP70i substrate-binding domain established the peptide QPGVLIQVYEG as invaluable for DC activation, and mutant HSP70i could not induce depigmentation. Moreover, mutant HSP70iQ435A bound human DCs and reduced their activation, as well as induced a shift from inflammatory to tolerogenic DCs in mice. HSP70iQ435A-encoding DNA applied months before spontaneous depigmentation prevented vitiligo in mice expressing a transgenic, melanocyte-reactive T cell receptor. Furthermore, use of HSP70iQ435Atherapeutically in a different, rapidly depigmenting model after loss of differentiated melanocytes resulted in 76% recovery of pigmentation. Treatment also prevented relevant T cells from populating mouse skin. In addition, ex vivo treatment of human skin averted the disease-related shift from quiescent to effector T cell phenotype. Thus, HSP70iQ435A DNA delivery may offer potent treatment opportunities for vitiligo.

Abstract en la página de Science Translational Medicine

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7 Comentarios

  1. Por favor hágame saber donde puedo comprar el tratamiento, la cantidad que necesito y el previo. Estoy muy preocupada porque mi hija de 6 años ha empezado con vililigo en su párpado derecho y por estar la mancha o despigmentación muy cerca de su ojo no quiero usar productos que pudieran perjudicar su visión. Estaré pendiente de su respuesta. Muchas gracias

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  2. Tengo vitíligo en todo el cuerpo ,doctor he pensado ir hasta chicago ilinois a concertar una cita con la doctora Lee Pole no se si sea buena idea o solo estaría gastando tiempo y dinero le he mandado correos y no me responde en un foro oi a un paciente en un foro que encontré que se había sometido a una fase de experimentación para probar el tratamiento ¿Es eso cierto que esta en fase experimental los que se desean inyectarse la proteína?
    ¿Tiene alguna idea de cuando saldrá ese tratamiento a base de inyectarse la proteína al mercado ?
    ¿aLGUN DIA VERA LA LUZ ESA PROTEINA?
    gracias por responder

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    • Hola Ruth,
      Salvo error, no hemos recibido ningún correo con la dirección que indicas. Respondemos a todos nuestros correos en un plazo inferior a 48 horas, salvo contadas excepciones.
      Hemos contestado a tus preguntas en otro apartado de la página en el que preguntas lo mismo. Aquí puedes ver nuestra respuesta: http://www.lumi-derm.com/vitiligo/vitiligo-genetica/
      Saludos cordiales
      Equipo Lumiderm

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  3. I apologize. I sent you my email and did not realized that as I typed, my key board placed the wrong word. I was referring to my daughter ‘s cheek. I was in a hurry and did not proof read my message.

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  4. My 15 year old develop vitiligo on one side of her face. It all started last year September 2013) with a tear like drop whit spot on her right side of her face. Today, July 21 2014, she has a big spot inher chick and part if her eye lid and nose. We have seen three dermatologist. The last doctor finally , diagnosed her with vitiligo. She is currently dying creams. The spot seems to be the same. It has not show any signs of spreading. However, as the summer has got here, her face got tan and the spot has become more noticie. As a teen she is feing very depress. Please help and let me know what studies is out there to help vitiligo patients. Thank you.
    Myriam Marin

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    • Hello Myriam,
      without any doubt this is segmental Vitiligo, a special form which has the big advantage that it can be cured completely if its treated correctly. I have many patientes with this special problem and they all are happy after 6 months.
      Please contact me at info@lumi-derm.com directly because the explications cannot be given in this public forum.

      Greetings from Madrid to wherever you live
      Andreas Overbeck

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